Vitamin D Deficiency, Rickets, and Hypervitaminosis D: Causes, Clinical Features, Diagnosis, and Management
Pathophysiology and Clinical Features of Rickets
Vitamin D is crucial for bone health. Deficiency leads to rickets and osteomalacia, while excess causes hypervitaminosis D. Proper intake and sunlight exposure are key to prevention.
Vitamin D Deficiency, Rickets, and Hypervitaminosis D: Causes, Clinical Features, Diagnosis, and Management
Introduction
Vitamin D plays a crucial role in calcium homeostasis and bone health. Deficiency can lead to rickets in children and osteomalacia in adults, while excess vitamin D can result in hypervitaminosis D.
Pathophysiology of Rickets
Role of Vitamin D in Bone Formation
Vitamin D enhances calcium and phosphate absorption, critical for bone mineralization. Insufficient levels result in defective bone formation.
Causes of Rickets
- Dietary deficiency
- Lack of sunlight exposure
- Genetic disorders affecting vitamin D metabolism
Clinical Features of Rickets
Common signs include bone pain, delayed growth, and skeletal deformities such as bowed legs.
Diagnosis and Management
Diagnosis
- Serum levels of 25-hydroxyvitamin D
- Radiographic evidence of bone deformities
Management
Includes vitamin D supplementation, dietary modifications, and adequate sun exposure.
Hypervitaminosis D
Excessive intake of vitamin D can lead to hypercalcemia, resulting in nephrocalcinosis and cardiovascular complications.
Conclusion
Balanced vitamin D intake is essential for optimal bone health. Prevention strategies should focus on proper nutrition and adequate sunlight exposure.
Tags
Recommended Reads
Explore related articles that might interest you
Causes, clinical features, diagnosis, and management of Vitamin D deficiency and excess (Rickets and Hypervitaminosis D)
Vitamin D Deficiency, Rickets, and Hypervitaminosis D: Causes, Clinical Features, Diagnosis, and Management
Vitamin D Deficiency, Rickets, and Hypervitaminosis D: Causes, Clinical Features, Diagnosis, and Management
Vitamin D Deficiency, Rickets, and Hypervitaminosis D: Causes, Clinical Features, Diagnosis, and Management
Causes, clinical features, diagnosis, and management of Vitamin D deficiency and excess (Rickets and Hypervitaminosis D)
Vitamin D Deficiency, Rickets, and Hypervitaminosis D: Causes, Clinical Features, Diagnosis, and Management
