Urticaria and Angioedema: Definition and Classification

Angioedema is a condition characterized by rapid swelling of the deeper layers of the skin and mucous membranes. It is often associated with urticaria but can occur independently.

Definition of Angioedema

Angioedema is caused by fluid leakage from blood vessels into surrounding tissues. It may result from allergic reactions, hereditary factors, or medication-induced effects.

Classification of Angioedema

Allergic Angioedema: Triggered by allergens such as food, insect stings, or medications.
Hereditary Angioedema (HAE): Caused by genetic mutations affecting the C1 inhibitor protein.
Idiopathic Angioedema: No identifiable cause, often chronic and recurring.
Medication-Induced Angioedema: Associated with drugs like ACE inhibitors.

Clinical Presentation

Symptoms of angioedema include swelling of the lips, tongue, face, and extremities. Severe cases may lead to airway obstruction, requiring immediate medical attention.