Diagnostic and Imaging Modalities for Evaluating Movement Disorders

PET and SPECT Imaging in Assessing Dopaminergic Dysfunction in Movement Disorders

Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are valuable neuroimaging techniques used to assess dopaminergic dysfunction in movement disorders such as Parkinson’s disease. These modalities allow for detailed visualization of dopamine transporter (DAT) activity, helping clinicians differentiate between various movement disorders.

PET Imaging

PET imaging utilizes radiotracers such as fluorodopa (18F-DOPA) to evaluate presynaptic dopamine synthesis and dopamine receptor binding. This imaging method provides high sensitivity in detecting early Parkinsonian changes.

SPECT Imaging

SPECT imaging commonly employs radiotracers such as Ioflupane (123I-FP-CIT) to assess DAT activity. It aids in distinguishing essential tremor from Parkinsonian syndromes, making it a valuable diagnostic tool.