Pathogenesis of Systemic Lupus Erythematosus
Immune System Dysregulation
Systemic Lupus Erythematosus is an autoimmune disease involving immune system dysregulation, autoantibody production, and inflammatory response leading to multi-organ damage.
Pathogenesis of Systemic Lupus Erythematosus
Immune System Dysregulation
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder characterized by dysregulation of the immune system, leading to widespread inflammation and tissue damage. The pathogenesis of SLE involves various genetic, environmental, and immunological factors.
Genetic and Environmental Triggers
Individuals with a genetic predisposition to SLE may develop the disease upon exposure to environmental triggers such as ultraviolet (UV) radiation, infections, and certain medications.
Autoantibody Production and Immune Dysregulation
- Loss of Tolerance: B cells produce autoantibodies against nuclear antigens like DNA and histones.
- Complement Activation: Failure in clearance mechanisms leads to excessive immune complexes.
- Inflammatory Cascade: Cytokine overproduction contributes to tissue damage.
Clinical Implications
The immune dysregulation in SLE results in multi-organ involvement, affecting the skin, joints, kidneys, and cardiovascular system. Common manifestations include lupus nephritis, arthritis, and cutaneous rashes.
Conclusion
Understanding the pathogenesis of SLE aids in the development of targeted therapies and improved management strategies for patients.
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