Pathophysiology of Burns

Inflammatory Response and Healing Process

Burn injuries trigger a complex physiological response involving inflammation, tissue repair, and systemic effects. Understanding the pathophysiology of burns is crucial for effective management and treatment.

Stages of Inflammatory Response

• Immediate Response: Release of inflammatory mediators such as histamine and prostaglandins.
• Vascular Changes: Increased capillary permeability leading to edema.
• Immune Activation: Recruitment of neutrophils and macrophages to combat infection.

Healing Process

• Hemostasis: Formation of a fibrin clot to prevent further damage.
• Proliferation: Fibroblast activation and collagen deposition.
• Remodeling: Reorganization of extracellular matrix to restore skin integrity.

Effective burn treatment involves managing fluid loss, preventing infections, and promoting tissue regeneration through medical interventions.