Hodgkin Lymphoma and Non-Hodgkin Lymphoma: Treatment Modalities and Therapeutic Approaches

Lymphomas are a type of cancer affecting the lymphatic system. There are two main types: Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). While both originate from lymphocytes, they have distinct characteristics and treatment approaches.

Understanding Lymphomas

Hodgkin Lymphoma (HL)

HL is identified by the presence of Reed-Sternberg cells. It commonly affects young adults and has a high cure rate.

Non-Hodgkin Lymphoma (NHL)

NHL is more diverse, comprising multiple subtypes that range from indolent to aggressive. It is more common in older adults.

Treatment Approaches

Hodgkin Lymphoma Treatment

Chemotherapy: ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) is the standard regimen.
Radiation Therapy: Used for early-stage disease.
Immunotherapy: Checkpoint inhibitors such as pembrolizumab.

Non-Hodgkin Lymphoma Treatment

Chemotherapy: CHOP regimen (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) is widely used.
Targeted Therapy: Rituximab for B-cell NHL.
Stem Cell Transplant: For refractory cases.