Amyloidosis in Pathology Specimens

Histopathological Features of Amyloidosis

Amyloidosis refers to a group of disorders characterized by extracellular deposition of abnormal amyloid protein. These proteins form beta-pleated sheets, leading to dysfunction in affected tissues.

Histopathological Characteristics

• Staining Techniques: Amyloid deposits exhibit apple-green birefringence under polarized light when stained with Congo red.
• Types of Amyloid: Different forms include AL (light chain), AA (reactive systemic), ATTR (transthyretin-related), and Aβ (associated with Alzheimer's disease).
• Organ Involvement: Commonly affected organs include kidneys, liver, heart, and nervous system.

Diagnostic Approaches

Histological examination using Congo red, electron microscopy, and immunohistochemistry can help confirm amyloidosis.

Treatment Considerations

Management depends on underlying cause and extent of organ involvement. Therapeutic approaches include chemotherapy, immunomodulatory treatments, and targeted therapy.