Histology of Connective Tissue

Extracellular Matrix: Composition and Function

Connective tissue plays a crucial role in structural support and intercellular communication. Its extracellular matrix (ECM) consists of fibers and ground substance, which provide mechanical stability and biochemical signaling.

Fibers in ECM

• Collagen fibers: The most abundant, providing tensile strength.
• Elastic fibers: Allow flexibility and elasticity in tissues.
• Reticular fibers: Form delicate networks supporting organs and cells.

Ground Substance

A hydrated gel-like material containing glycoproteins and proteoglycans that facilitate nutrient transport and cellular adhesion.

Functions of ECM Components

• Structural integrity and resilience of tissues.
• Facilitation of cellular communication.
• Regulation of biochemical signaling.