Gastrointestinal and Endocrine Drugs: Insulin
Toxicology and Adverse Effects of Insulin Overdose
Insulin overdose can lead to severe hypoglycemia, causing neurological and systemic complications. Proper medical supervision and forensic analysis are necessary for managing such cases.
Gastrointestinal and Endocrine Drugs: Insulin
Toxicology and Adverse Effects of Insulin Overdose
Insulin, a life-saving hormone for diabetic patients, can become dangerous when administered in excessive amounts. Insulin overdose leads to severe hypoglycemia, resulting in neurological and systemic complications.
Mechanism of Insulin Toxicity
Insulin lowers blood glucose levels by promoting glucose uptake into cells and inhibiting hepatic glucose production. Excessive administration can cause a sharp decline in blood glucose, leading to hypoglycemia.
Symptoms of Insulin Overdose
- Confusion and dizziness
- Seizures
- Loss of consciousness
- Tachycardia and sweating
Forensic Implications of Insulin Toxicity
Cases of insulin overdose in forensic medicine range from accidental overdosing to malicious intent, making it a subject of toxicological investigations.
Management of Insulin Overdose
- Immediate glucose administration
- Monitoring of blood glucose levels
- Hospitalization for continuous observation
Conclusion
While insulin remains indispensable for diabetic patients, its overdose can have fatal consequences. Proper medical supervision and forensic analysis are crucial in managing and investigating such cases.