Gastric Function Tests: Secretin Stimulation Test for Pancreatic Secretion

The secretin stimulation test is a diagnostic tool used to assess the functionality of the pancreas by measuring its response to secretin, a hormone that stimulates bicarbonate and enzyme secretion. This test plays a crucial role in diagnosing conditions such as chronic pancreatitis and pancreatic insufficiency.

What is Secretin?

Secretin is a hormone produced by the small intestine in response to acidic stomach contents. It signals the pancreas to release bicarbonate-rich fluid to neutralize the acid and optimize digestion.

Procedure of the Secretin Stimulation Test

• The patient fasts overnight to ensure accurate readings.
• Secretin is administered intravenously.
• Pancreatic secretions are collected via a duodenal tube.
• The bicarbonate and enzyme levels are measured to determine pancreatic function.

Clinical Significance

This test helps identify pancreatic disorders, aiding in the diagnosis of conditions like cystic fibrosis, chronic pancreatitis, and Zollinger-Ellison syndrome.