Etiology, Pathogenesis, Pathology, and Clinical Features of Oral Cancer
Etiology: Genetic, Environmental, and Lifestyle Factors Influencing Oral Cancer
Oral cancer arises due to genetic, environmental, and lifestyle factors. Early detection and risk mitigation can significantly improve outcomes.
6/6/2025• 6 min read• 47 views
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Etiology, Pathogenesis, Pathology, and Clinical Features of Oral Cancer
Etiology: Genetic, Environmental, and Lifestyle Factors Influencing Oral Cancer
Oral cancer is a multifactorial disease influenced by genetic predisposition, environmental exposures, and lifestyle habits. Understanding these contributing factors is crucial for prevention and early detection.
Genetic Factors
- Mutations in tumor suppressor genes such as TP53 and PIK3CA.
- Familial history of cancer increasing susceptibility.
- Epigenetic modifications impacting cellular growth.
Environmental Factors
- Exposure to carcinogens such as tobacco smoke and alcohol.
- Chronic infections with HPV and other oncogenic viruses.
- Prolonged exposure to UV radiation, especially for lip cancers.
Lifestyle Factors
- Chewing tobacco and betel quid linked to high oral cancer prevalence.
- Poor dietary habits, including deficiencies in vitamins A, C, and E.
- Occupational hazards like exposure to chemical irritants.
Tags
#Oral Cancer#Genetic Mutations#Tobacco#HPV Infection#Pathology
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