Pharmacology, Therapeutic Uses, Adverse Effects, and Drug Interactions of Thyroxine and Antithyroid Medications

Thyroid disorders require precise pharmacological management using thyroxine or antithyroid medications. Understanding drug interactions is critical to ensuring optimal therapeutic outcomes.

Drug Interactions of Antithyroid Medications

Antithyroid drugs, such as methimazole and propylthiouracil, interact with various medications, which may alter efficacy or increase adverse effects.

Common Drug Interactions

• Warfarin: Antithyroid drugs may decrease the anticoagulant effects of warfarin, necessitating dose adjustments.
• Beta-blockers: Concurrent use may enhance the symptomatic relief of hyperthyroidism.
• Theophylline: Clearance of theophylline may be reduced, leading to toxicity.

Managing Drug Interactions

Healthcare providers should carefully monitor thyroid function and medication adjustments to mitigate risks associated with drug interactions.