Pharmacological Treatment of Leprosy Based on National Guidelines
Dosage and duration of MDT treatment
The national guidelines for leprosy treatment emphasize the use of multidrug therapy (MDT) to prevent resistance and ensure complete eradication of Mycobacterium leprae.
Pharmacological Treatment of Leprosy Based on National Guidelines
Introduction
Leprosy, caused by Mycobacterium leprae, requires a multidrug therapy (MDT) approach to effectively cure and prevent resistance. National guidelines provide standardized treatment protocols to ensure effective disease management.
MDT Treatment: Dosage and Duration
Classification-Based Treatment
- Paucibacillary Leprosy: Rifampicin (600 mg/month) and Dapsone (100 mg/day) for 6 months.
- Multibacillary Leprosy: Rifampicin (600 mg/month), Clofazimine (300 mg/month, 50 mg/day), and Dapsone (100 mg/day) for 12 months.
Special Considerations
For pediatric patients and individuals with contraindications, adjustments in dosage and alternative regimens are recommended.
Adverse Effects and Monitoring
MDT drugs can lead to gastrointestinal symptoms, skin pigmentation, and hemolysis in G6PD-deficient patients. Regular follow-up ensures early detection and management of side effects.
Conclusion
National guidelines help standardize the effective treatment of leprosy, ensuring cure and reducing transmission. MDT remains the cornerstone of management.
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Pharmacological Treatment of Leprosy Based on National Guidelines
