Differential Diagnosis of Diarrhea

Medication-Induced Diarrhea

Diarrhea can be a side effect of various medications. Understanding the underlying causes is crucial for appropriate management.

Common Medications Causing Diarrhea

• Antibiotics: These disrupt gut flora, leading to diarrhea. Examples include amoxicillin and clindamycin.
• Laxatives: Overuse can lead to dependency and chronic diarrhea. Examples include senna and polyethylene glycol.
• Chemotherapeutic Agents: Drugs like fluorouracil and methotrexate can irritate the intestinal lining, causing diarrhea.

Mechanisms Leading to Medication-Induced Diarrhea

Several mechanisms contribute to this condition:

• Changes in gut microbiota (antibiotics)
• Increased intestinal motility (laxatives)
• Direct irritation of the intestinal mucosa (chemotherapeutic agents)

Clinical Management

Management strategies include discontinuing or modifying medication, using probiotics, and maintaining hydration.

When to Seek Medical Attention

Persistent or severe diarrhea should be evaluated by a healthcare provider, especially if accompanied by dehydration or weight loss.