Development of the Urinary System
Development of the Ureteric Bud and Metanephric Blastema
The development of the urinary system is guided by interactions between the ureteric bud and the metanephric blastema, shaping kidney formation.
Development of the Urinary System
Development of the Ureteric Bud and Metanephric Blastema
The development of the urinary system is a complex process that begins early in embryogenesis. The interaction between the ureteric bud and the metanephric blastema plays a critical role in forming the definitive kidney.
Formation of the Ureteric Bud
The ureteric bud is an outgrowth from the mesonephric duct. It penetrates the metanephric mesenchyme, initiating reciprocal signaling that leads to the differentiation of nephrons.
Induction of the Metanephric Blastema
The metanephric blastema is a cluster of mesenchymal cells that respond to signals from the ureteric bud. This interaction leads to the formation of glomeruli, tubules, and the renal pelvis.
Branching Morphogenesis
As the ureteric bud expands, it undergoes branching morphogenesis, forming the collecting duct system. Defects in this process can result in congenital kidney abnormalities.
Clinical Significance
Improper development of the ureteric bud or metanephric blastema can lead to conditions such as renal agenesis, polycystic kidney disease, and hydronephrosis.
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