Principles of Highly Active Antiretroviral Therapy (HAART) and Classes of Antiretroviral Drugs
Classification of antiretroviral drugs based on mechanism of action
Highly Active Antiretroviral Therapy (HAART) utilizes a combination of antiretroviral drugs to effectively treat HIV. These drugs are classified based on their mechanisms of action, including reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, entry inhibitors, and pharmacokinetic enhancers.
Principles of Highly Active Antiretroviral Therapy (HAART) and Classes of Antiretroviral Drugs
Highly Active Antiretroviral Therapy (HAART) is a combination of drugs used to treat HIV infection effectively.
Classification of Antiretroviral Drugs
Antiretroviral drugs are categorized based on their mechanism of action:
1. Reverse Transcriptase Inhibitors (RTIs)
- Nucleoside Reverse Transcriptase Inhibitors (NRTIs) - Prevent viral replication by inhibiting reverse transcriptase.
- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) - Directly inhibit reverse transcriptase activity.
2. Protease Inhibitors (PIs)
Block the function of viral protease enzymes, preventing viral maturation.
3. Integrase Inhibitors
Prevent the integration of viral DNA into the host genome.
4. Entry Inhibitors
Stop the virus from entering host cells by targeting cellular receptors.
5. Pharmacokinetic Enhancers
Improve drug bioavailability and efficacy.
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Principles of Highly Active Antiretroviral Therapy (HAART)
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