Pharmacological Treatment of Leprosy Based on National Guidelines
Adverse effects and contraindications of leprosy medications
National guidelines recommend a multi-drug therapy approach for leprosy management, incorporating Rifampicin, Dapsone, and Clofazimine while addressing contraindications and side effects.
Pharmacological Treatment of Leprosy Based on National Guidelines
Introduction
Leprosy, caused by Mycobacterium leprae, requires a standardized pharmacological approach for effective treatment. National guidelines recommend multi-drug therapy (MDT) to prevent resistance and ensure complete eradication.
Recommended Medications
Rifampicin
- Primary bactericidal drug in MDT.
- Contraindications: Severe hepatic impairment.
- Adverse effects: Hepatotoxicity, flu-like syndrome.
Dapsone
- Works by inhibiting bacterial folate synthesis.
- Contraindications: G6PD deficiency.
- Adverse effects: Hemolysis, methemoglobinemia.
Clofazimine
- Anti-inflammatory effects beneficial for leprosy reactions.
- Contraindications: Hypersensitivity.
- Adverse effects: Skin discoloration, gastrointestinal disturbances.
Monitoring and Side Effects Management
Regular follow-ups are crucial to identify drug reactions early. Patients with high-risk contraindications should be monitored closely with liver function tests and hemoglobin levels.
Conclusion
Adherence to national guidelines ensures effective leprosy management while minimizing adverse effects. Awareness about contraindications improves patient safety.
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